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instability, and neuromuscular symptoms) has been described following the concomitant use of 5-HT 3 receptor antagonists and other serotonergic drugs, including SSRIs and SNRIs Monitor for the emergence of serotonin syndrome Apr 4, 2023 · Experts aren't sure exactly how Zofran (ondansetron) works and if its antiemetic action is mediated by a direct effect on the CTZ (the area of the brain associated with vomiting), the vagus nerve, or both Zofran is a selective 5‑HT3 receptor antagonist and the neurotransmitter, serotonin, appears to play a role in ondansetron's effect reference medscape com drug ondansetron-342052--- rxlist com zofran-drug htmAug 1, 2023 · Zofran blocks the actions of chemicals in the body that can trigger nausea and vomiting Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment Zofran may be used for purposes not listed in this medication guide Warningsyoutube com--- drugs com tips 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